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Title: | Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status |
Authors: | Ghahremani, M Smith, EE Chen, H-Y Creese, B Goodarzi, Z Ismail, Z |
Keywords: | apolipoprotein E ε4 status;clinical cognitive diagnosis;Cox proportional hazards model;dementia;modifiable risk factors;sex;survival analysis;vitamin D deficiency;vitamin D supplementation |
Issue Date: | 1-Mar-2023 |
Publisher: | Wiley on behalf of Alzheimer's Association. |
Citation: | Ghahremani, M. et al. (2023) 'Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 15 (1), e12404, pp. 1 - 11. doi: 10.1002/dad2.12404. |
Abstract: | Copyright © 2023 The Authors. Introduction: Despite the association of vitamin D deficiency with incident dementia, the role of supplementation is unclear. We prospectively explored associations between vitamin D supplementation and incident dementia in 12,388 dementia-free persons from the National Alzheimer's Coordinating Center. Methods: Baseline exposure to vitamin D was considered D+; no exposure prior to dementia onset was considered D−. Kaplan–Meier curves compared dementia-free survival between groups. Cox models assessed dementia incidence rates across groups, adjusted for age, sex, education, race, cognitive diagnosis, depression, and apolipoprotein E (APOE) ε4. Sensitivity analyses examined incidence rates for each vitamin D formulation. Potential interactions between exposure and model covariates were explored. Results: Across all formulations, vitamin D exposure was associated with significantly longer dementia-free survival and lower dementia incidence rate than no exposure (hazard ratio = 0.60, 95% confidence interval: 0.55–0.65). The effect of vitamin D on incidence rate differed significantly across the strata of sex, cognitive status, and APOE ε4 status. Discussion: Vitamin D may be a potential agent for dementia prevention. Highlights: * In a prospective cohort study, we assessed effects of Vitamin D on dementia incidence in 12,388 participants from the National Alzheimer's Coordinating Center dataset. * Vitamin D exposure was associated with 40% lower dementia incidence versus no exposure. * Vitamin D effects were significantly greater in females versus males and in normal cognition versus mild cognitive impairment. * Vitamin D effects were significantly greater in apolipoprotein E ε4 non-carriers versus carriers. * Vitamin D has potential for dementia prevention, especially in the high-risk strata. |
Description: | Supporting Information is available online at: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12404#support-information-section . |
URI: | https://bura.brunel.ac.uk/handle/2438/27649 |
DOI: | https://doi.org/10.1002/dad2.12404 |
Other Identifiers: | ORCID iD: https://orcid.org/0000-0001-6490-6037 e12404 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2023 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | 1.02 MB | Adobe PDF | View/Open |
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