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Title: The neuroanatomy of visual extinction following right hemisphere brain damage: Insights from multivariate and Bayesian lesion analyses in acute stroke
Authors: Sperber, C
Wiesen, D
Karnath, H-O
de Haan, B
Keywords: visual extinction;selective attention;support vector regression;VLSM;temporo-parietal junction;intraparietal sulcus
Issue Date: 6-Feb-2024
Publisher: Wiley
Citation: Sperber, C. et al. (2024) 'The neuroanatomy of visual extinction following right hemisphere brain damage: Insights from multivariate and Bayesian lesion analyses in acute stroke', Human Brain Mapping, 0 (accepted, in press), pp. 1 - 42..
Abstract: Multi-target attention, i.e. the ability to attend and respond to multiple visual targets presented simultaneously on the horizontal meridian across both visual fields, is essential for everyday real-world behaviour. Given the close link between the neuropsychological deficit of extinction and attentional limits in healthy subjects, investigating the anatomy that underlies extinction is uniquely capable of providing important insights concerning the anatomy critical for normal multi-target attention. Previous studies into the brain areas critical for multi-target attention and its failure in extinction patients have, however, produced heterogeneous results. In the current study, we used multivariate and Bayesian lesion analysis approaches to investigate the anatomical substrate of visual extinction in a large sample of 108 acute right hemisphere stroke patients. The use of acute stroke patient data and multivariate/Bayesian lesion analysis approaches allowed us to address limitations associated with previous studies and so obtain a more complete picture of the functional network associated with visual extinction. Our results demonstrate that the right temporo-parietal junction (TPJ) is critically associated with visual extinction. The Bayesian lesion analysis additionally implicated the right intraparietal sulcus (IPS), in line with the results of studies in neurologically healthy participants that highlighted the IPS as the area critical for multi-target attention. Our findings resolve the seemingly conflicting previous findings, and emphasise the urgent need for further research to clarify the precise cognitive role of the right TPJ in multi-target attention and its failure in extinction patients.
Description: Data availability statement: Online materials are publicly available at OSF under a CC BY license: These include descriptive and statistical topographies and extended demographic data. The clinical datasets analysed in the current study are not publicly available due to the data protection agreement approved by the local ethics committee.
Patient consent statement: Patients or their relatives consented to the scientific re-use of their data. The study was performed in accordance with the ethical standards laid down in the 2013 Declaration of Helsinki.
A PsyArXiv preprint is available online at: . It has not been certified by peer review.
ISSN: 1065-9471
Other Identifiers: ORCID iD: Christoph Sperber
ORCID iD: Hans-Otto Karnath
ORCID iD: Daniel Wiesen
ORCID iD: Bianca de Haan
Appears in Collections:Dept of Life Sciences Embargoed Research Papers

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