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Title: | Cognitive and Mental Health Trajectories of COVID-19: Role of Hospitalisation and Long-COVID Symptoms |
Authors: | Vakani, K Ratto, M Sandford-James, A Antonova, E Kumari, V |
Keywords: | cognitive function;COVID-19 trajectory;long-COVID;intra-individual variability;processing speed |
Issue Date: | 5-Feb-2024 |
Publisher: | Cambridge University Press on behalf of European Psychiatric Association |
Citation: | Vakani, K. et al. (2024) 'Cognitive and Mental Health Trajectories of COVID-19: Role of Hospitalisation and Long-COVID Symptoms', European Psychiatry, 67 (1), , e17, pp. 1 - 12. doi: 10.1192/j.eurpsy.2024.7. |
Abstract: | Background: There is considerable evidence of cognitive impairment post COVID-19, especially in individuals with long-COVID symptoms, but limited research objectively evaluating whether such impairment attenuates or resolves over time, especially in young and middle-aged adults. Methods: Follow-up assessments (T2) of cognitive function (processing speed, attention, working memory, executive function, memory) and mental health were conducted in 138 adults (18-69 years) who had been assessed six months earlier (T1). Of these, 88 had a confirmed history of COVID-19 at T1 assessment (≥20 days post-diagnosis) and were also followed-up on COVID-19 related symptoms (acute and long-COVID); 50 adults had no known COVID-19 history at any point up to their T2 assessment. Results: From T1 to T2, a trend-level improvement occurred in intra-individual variability in processing speed in the COVID, relative to the non-COVID group. However, longer response/task completion times persisted in participants with COVID-19 related hospitalisation relative to those without COVID-19 related hospitalisation and non-COVID controls. There was a significant reduction in long-COVID symptom load, which correlated with improved executive function in non-hospitalised COVID-19 participants. The COVID group continued to self-report poorer mental health, irrespective of hospitalisation history, relative to non-COVID group. Conclusions: Although some cognitive improvement has occurred over a six-month period in young and middle-aged COVID-19 survivors, cognitive impairment persists in those with a history of COVID-19 related hospitalisation and/or long-COVID symptoms. Continuous follow-up assessments are required to determine whether cognitive function improves or possibly worsens, over time in hospitalised and long-COVID participants. |
Description: | Supplementary material: The supplementary material for this article can be found at https://doi.org/10.1192/j.eurpsy.2024.7 . |
URI: | https://bura.brunel.ac.uk/handle/2438/28318 |
DOI: | https://doi.org/10.1192/j.eurpsy.2024.7 |
ISSN: | 0924-9338 |
Other Identifiers: | ORCiD: Elena Antonova https://orcid.org/0000-0003-1624-3202 ORCiD: Veena Kumari https://orcid.org/0000-0002-9635-5505 e17 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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