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Title: | MRI techniques for immunotherapy monitoring |
Authors: | Lau, D Corrie, PG Gallagher, FA |
Issue Date: | 19-Sep-2022 |
Publisher: | BMJ Publishing Group |
Citation: | Lau, D., Corrie, P.G. and Gallagher, F.A. (2022) 'MRI techniques for immunotherapy monitoring', Journal for ImmunoTherapy of Cancer, 10 (9), e004708, pp. 1 - 17. doi: 10.1136/jitc-2022-004708. |
Abstract: | MRI is a widely available clinical tool for cancer diagnosis and treatment monitoring. MRI provides excellent soft tissue imaging, using a wide range of contrast mechanisms, and can non-invasively detect tissue metabolites. These approaches can be used to distinguish cancer from normal tissues, to stratify tumor aggressiveness, and to identify changes within both the tumor and its microenvironment in response to therapy. In this review, the role of MRI in immunotherapy monitoring will be discussed and how it could be utilized in the future to address some of the unique clinical questions that arise from immunotherapy. For example, MRI could play a role in identifying pseudoprogression, mixed response, T cell infiltration, cell tracking, and some of the characteristic immune-related adverse events associated with these agents. The factors to be considered when developing MRI imaging biomarkers for immunotherapy will be reviewed. Finally, the advantages and limitations of each approach will be discussed, as well as the challenges for future clinical translation into routine clinical care. Given the increasing use of immunotherapy in a wide range of cancers and the ability of MRI to detect the microstructural and functional changes associated with successful response to immunotherapy, the technique has great potential for more widespread and routine use in the future for these applications. |
Description: | Supplementary materials: supplementary data are available online at: https://jitc.bmj.com/content/10/9/e004708#supplementary-materials . Correction: MRI techniques for immunotherapy monitoring, https://doi.org/10.1136/jitc-2022-004708corr1 . Lau D, Corrie PG, Gallagher FAMRI techniques for immunotherapy monitoring. J Immunother Cancer 2022;10:e004708. doi: 10.1136/jitc-2022-004708. The author Ferdia A Gallagher has had the following affiliation added: Cancer Research UK Cambridge Centre, University of Cambridge. |
URI: | https://bura.brunel.ac.uk/handle/2438/29409 |
DOI: | https://doi.org/10.1136/jitc-2022-004708 |
Other Identifiers: | ORCiD: Doreen Lau https://orcid.org/0000-0002-7623-2401 ORCiD: Pippa G Corrie https://orcid.org/0000-0003-4875-7021 ORCiD: Ferdia A Gallagher https://orcid.org/0000-0003-4784-5230 e004708 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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