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Title: | In vivo cell tracking using pet: Opportunities and challenges for clinical translation in oncology |
Authors: | Lechermann, LM Lau, D Attili, B Aloj, L Gallagher, FA |
Keywords: | cell therapy;immunotherapy;cell tracking;PET/CT;PET/MRI;direct cell labelling;reporter genes;immuno-PET |
Issue Date: | 11-Aug-2021 |
Publisher: | MDPI |
Citation: | Lechermann, L.M. et al. (2021) 'In vivo cell tracking using pet: Opportunities and challenges for clinical translation in oncology', Cancers, 13 (16), 4042, pp. 1 - 19. doi: 10.3390/cancers13164042. |
Abstract: | Cell therapy is a rapidly evolving field involving a wide spectrum of therapeutic cells for personalised medicine in cancer. In vivo imaging and tracking of cells can provide useful information for improving the accuracy, efficacy, and safety of cell therapies. This review focuses on radiopharmaceuticals for the non-invasive detection and tracking of therapeutic cells using positron emission tomography (PET). A range of approaches for imaging therapeutic cells is discussed: Direct ex vivo labelling of cells, in vivo indirect labelling of cells by utilising gene reporters, and detection of specific antigens expressed on the target cells using antibody-based radiopharmaceuticals (immuno-PET). This review examines the evaluation of PET imaging methods for therapeutic cell tracking in preclinical cancer models, their role in the translation into patients, first-in-human studies, as well as the translational challenges involved and how they can be overcome. |
Description: | Data Availability Statement: Not applicable. |
URI: | https://bura.brunel.ac.uk/handle/2438/29416 |
DOI: | https://doi.org/10.3390/cancers13164042 |
Other Identifiers: | ORCiD: Laura M. Lechermann https://orcid.org/0000-0002-2742-6269 ORCiD: Doreen Lau https://orcid.org/0000-0002-7623-2401 ORCiD: Luigi Aloj https://orcid.org/0000-0002-7452-4961 ORCiD: Ferdia A. Gallagher https://orcid.org/0000-0003-4784-5230 4042 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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