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Title: Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations
Authors: Meaburn, KJ
Levy, N
Toniolo, D
Bridger, JM
Issue Date: 2005
Publisher: Portland Press
Citation: Biochemical Society Transactions. 33 ( 6) 1438-1440
Abstract: Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins. In the last decade, a number of diseases associated with tissue degeneration and premature aging have been linked with mutations in lamin A or emerin. These are termed laminopathies, withmutations in emerin causing Emery–Dreifuss muscular dystrophy. Despite highly aberrant nuclear distributions of A-type lamins and emerin in lymphoblastoid cell lines derived from patients with emerin or lamin A mutations, little or no change in chromosome location was detected.
ISSN: 0300-5127
Appears in Collections:Biological Sciences
Dept of Life Sciences Research Papers

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