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http://bura.brunel.ac.uk/handle/2438/2959
Title: | Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations |
Authors: | Meaburn, KJ Levy, N Toniolo, D Bridger, JM |
Issue Date: | 2005 |
Publisher: | Portland Press |
Citation: | Biochemical Society Transactions. 33 ( 6) 1438-1440 |
Abstract: | Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins. In the last decade, a number of diseases associated with tissue degeneration and premature aging have been linked with mutations in lamin A or emerin. These are termed laminopathies, withmutations in emerin causing Emery–Dreifuss muscular dystrophy. Despite highly aberrant nuclear distributions of A-type lamins and emerin in lymphoblastoid cell lines derived from patients with emerin or lamin A mutations, little or no change in chromosome location was detected. |
URI: | http://bura.brunel.ac.uk/handle/2438/2959 |
ISSN: | 0300-5127 |
Appears in Collections: | Biological Sciences Dept of Life Sciences Research Papers |
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File | Description | Size | Format | |
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0331438.pdf | 259.34 kB | Adobe PDF | View/Open |
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