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Title: | Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis |
Authors: | Kennedy, E Liebel, SW Lindsey, HM Vadlamani, S Lei, PW Adamson, MM Alda, M Alonso-Lana, S Anderson, TJ Arango, C Asarnow, RF Avram, M Ayesa-Arriola, R Babikian, T Banaj, N Bird, LJ Borgwardt, S Brodtmann, A Brosch, K Caeyenberghs, K Calhoun, VD Chiaravalloti, ND Cifu, DX Crespo-Facorro, B Dalrymple-Alford, JC Dams-O’Connor, K Dannlowski, U Darby, D Davenport, N DeLuca, J Diaz-Caneja, CM Disner, SG Dobryakova, E Ehrlich, S Esopenko, C Ferrarelli, F Frank, LE Franz, CE Fuentes-Claramonte, P Genova, H Giza, CC Goltermann, J Grotegerd, D Gruber, M Gutierrez-Zotes, A Ha, M Haavik, J Hinkin, C Hoskinson, KR Hubl, D Irimia, A Jansen, A Kaess, M Kang, X Kenney, K Keřková, B Khlif, MS Kim, M Kindler, J Kircher, T Knížková, K Kolskår, KK Krch, D Kremen, WS Kuhn, T Kumari, V Kwon, J Langella, R Laskowitz, S Lee, J Lengenfelder, J Liou-Johnson, V Lippa, SM Løvstad, M Lundervold, AJ Marotta, C Marquardt, CA Mattos, P Mayeli, A McDonald, CR Meinert, S Melzer, TR Merchán-Naranjo, J Michel, C Morey, RA Mwangi, B Myall, DJ Nenadić, I Newsome, MR Nunes, A O’Brien, T Oertel, V Ollinger, J Olsen, A Ortiz García de la Foz, V Ozmen, M Pardoe, H Parent, M Piras, F Piras, F |
Keywords: | verbal learning;memory;dementia;depression;Parkinson’s disease;schizophrenia;stroke;traumatic brain injury;bipolar disorder;attention-deficit/hyperactivity disorder |
Issue Date: | 29-Jun-2024 |
Publisher: | MDPI |
Citation: | Kennedy, E. et al. (2024) 'Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis', Brain Sciences, 14 (7), 669, pp. 1 - 21. doi: 10.3390/brainsci14070669. |
Abstract: | Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15–90. The effects of dementia, mild cognitive impairment, Parkinson’s disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals. Random forest models identified age, years of education, and site as important VLM covariates. A Bayesian harmonization approach was used to isolate and remove site effects. Regression estimated the adjusted association of each clinical group with VLM scores. Memory deficits were strongly associated with dementia and schizophrenia (p < 0.001), while neither depression nor ADHD showed consistent associations with VLM scores (p > 0.05). Differences associated with clinical conditions were larger for longer delayed recall duration items. By comparing VLM across clinical conditions, this study provides a foundation for enhanced diagnostic precision and offers new insights into disease management of comorbid disorders. |
Description: | Data Availability Statement: The raw data supporting the conclusions of this article and code used for analysis will be made available by the authors on reasonable request pending appropriate study approvals and data transfer agreements between participating institutions. Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/brainsci14070669/s1, Table S1: Inclusion/exclusion criteria for each data source; Table S2: Deficit in words recalled for each clinical condition relative to matched controls. Refs. [61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100] are cited in the Supplementary Materials. |
URI: | https://bura.brunel.ac.uk/handle/2438/29709 |
DOI: | https://doi.org/10.3390/brainsci14070669 |
Other Identifiers: | ORCiD: Hannah M. Lindsey https://orcid.org/0000-0003-3826-854X ORCiD: Emily L. Dennis https://orcid.org/0000-0001-7112-4009 ORCiD: Veena Kumari https://orcid.org/0000-0002-9635-5505 669 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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