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Title: | Evidence for exercise-based interventions across 45 different long-term conditions: an overview of systematic reviews |
Authors: | Dibben, GO Gardiner, L Young, HML Wells, V Evans, RA Ahmed, Z Barber, S Dean, S Doherty, P Gardiner, N Greaves, C Ibbotson, T Jani, BD Jolly, K Mair, FS McIntosh, E Ormandy, P Simpson, SA Ahmed, S Krauth, SJ Steell, L Singh, SJ Taylor, RS Begum, S DeBarros, C Davies, F Sterniczuk, K Kumar, R Longley, R Freeman, A Lalseta, J Ashby, P Van Grieken, M Grace Elder, D |
Keywords: | long-term conditions;exercise;physical activity;systematic review;overview |
Issue Date: | 29-Apr-2024 |
Publisher: | Elsevier |
Citation: | Dibben, G.O.D. et al on behalf of the PERFORM research team (2024) 'Evidence for exercise-based interventions across 45 different long-term conditions: an overview of systematic reviews', eClinicalMedicine, 2024, 72, 102599. pp. 1 - 14. doi: 10.1016/j.eclinm.2024.102599. |
Abstract: | Background: Almost half of the global population face significant challenges from long-term conditions (LTCs) resulting in substantive health and socioeconomic burden. Exercise is a potentially key intervention in effective LTC management. Methods: In this overview of systematic reviews (SRs), we searched six electronic databases from January 2000 to October 2023 for SRs assessing health outcomes (mortality, hospitalisation, exercise capacity, disability, frailty, health-related quality of life (HRQoL), and physical activity) related to exercise-based interventions in adults (aged >18 years) diagnosed with one of 45 LTCs. Methodological quality was assessed using AMSTAR-2. International Prospective Resister of Systematic Reviews (PROSPERO) ID: CRD42022319214. Findings: Forty-two SRs plus three supplementary RCTs were included, providing 990 RCTs in 936,825 people across 39 LTCs. No evidence was identified for six LTCs. Predominant outcome domains were HRQoL (82% of SRs/RCTs) and exercise capacity (66%); whereas disability, mortality, physical activity, and hospitalisation were less frequently reported (≤25%). Evidence supporting exercise-based interventions was identified in 25 LTCs, was unclear for 13 LTCs, and for one LTC suggested no effect. No SRs considered multimorbidity in the delivery of exercise. Methodological quality varied: critically-low (33%), low (26%), moderate (26%), and high (12%). Interpretation: Exercise-based interventions improve HRQoL and exercise capacity across numerous LTCs. Key evidence gaps included limited mortality and hospitalisation data and consideration of multimorbidity impact on exercise-based interventions. |
Description: | Data sharing statement:
Data collected for the study will be made available on request to the corresponding author. Supplementary data are available online at: https://www.sciencedirect.com/science/article/pii/S2589537024001780#appsec1 . |
URI: | https://bura.brunel.ac.uk/handle/2438/30223 |
DOI: | https://doi.org/10.1016/j.eclinm.2024.102599 |
Other Identifiers: | ORCiD: Grace O. Dibben https://orcid.org/0000-0002-7254-5187 ORCiD: Lucy Gardiner https://orcid.org/0000-0002-0964-6567 ORCiD: Nikki Gardiner https://orcid.org/0000-0002-5098-3645 ORCiD: Sayem Ahmed https://orcid.org/0000-0001-9499-1500 ORCiD: Lewis Steell https://orcid.org/0000-0002-4010-1469 ORCiD: Rod S. Taylor https://orcid.org/0000-0002-3043-6011 102599 |
Appears in Collections: | Dept of Health Sciences Research Papers |
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