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http://bura.brunel.ac.uk/handle/2438/3085
Title: | Telomere length abnormalities in mammalian radiosensitive cells |
Authors: | McIllrath, J Bouffler, SD Samper, E Cuthbert, AP Wojcik, A Szumiel, I Bryant, PE Riches, AC Slijepcevic, P Newbold, RF |
Keywords: | 3T3 Cells;Animals;Breast Neoplasms/blood/genetics;Chromosome Aberrations;Chromosomes/*radiation effects;Humans |
Issue Date: | 2001 |
Publisher: | American Association for Cancer Research |
Citation: | Cancer Research. 61 (3) 912-915 |
Abstract: | Telomere lengths in radiosensitive murine lymphoma cells L5178Y-S and parental radioresistant L5178Y cells were measured by quantitative fluorescence in situ hybridization. Results revealed a 7-fold reduction in telomere length in radiosensitive cells (7 kb) in comparison with radioresistant cells (48 kb). Therefore, it was reasoned that telomere length might be used as a marker for chromosomal radiosensitivity. In agreement with this hypothesis, a significant inverse correlation between telomere length and chromosomal radiosensitivity was observed in lymphocytes from 24 breast cancer patients and 5 normal individuals. In contrast, no chromosomal radiosensitivity was observed in mouse cell lines that showed shortened telomeres, possibly reflecting differences in radiation responses between primary cells and established cell lines. Telomere length abnormalities observed in radiosensitive cells suggest that these two phenotypes may be linked. |
URI: | http://bura.brunel.ac.uk/handle/2438/3085 |
ISSN: | 0008-5472 |
Appears in Collections: | Biological Sciences Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
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Embargoed Paper.txt | 204 B | Text | View/Open |
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