Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/31684
Title: Towards a new Value-based scenario for the management of dementia in Italy: a SINdem delphi consensus study
Authors: Marra, C
Beccia, F
Caffarra, P
L’Abbate, F
Agosta, F
Benussi, A
Bonanni, L
Bruni, AC
Bruno, G
Cappa, SF
Cerami, C
Di Lorenzo, F
Ferrarese, C
Galimberti, D
Guarnieri, B
Mariani, C
Nacmias, B
Pantoni, L
Piccoli, T
Perani, D
Rainero, I
Tagliavini, F
Venneri, A
Boccia, S
Cagnin, A
Calabrò, GE
Bozzali, M
Zuffi, M
Zanusso, G
Vista, M
Vacca, A
Tripi, G
Tognoni, G
Tiraboschi, P
Sucapane, P
Spallazzi, M
Sibilia, G
Sensi, S
Rubino, E
Rosso, M
Roncacci, S
Puccio, G
Plutino, A
Parnetti, L
Pardini, M
Parchi, P
Orsini, AVM
Musso, AM
Mura, G
Monastero, R
Moda, F
Merlo, P
Mei, D
Mecocci, P
Giuseppina Mascia, M
Martorana, A
Marti, A
Marcon, M
Malagù, S
Luzzi, S
Luiselli, D
Luca, A
Isella, V
Imperiale, D
Iavarone, A
Guarino, M
Gragnaniello, D
Giubilei, F
Forloni, G
Floris, G
Fiori, C
Filippi, M
Farina, E
Fabi, K
Esposito, S
Di Giorgi, L
Della Rocca, G
De Togni, L
Colao, R
Ceci, M
Capellari, S
Canu, EDG
Bessi, V
Bellelli, G
Baschi, R
Babiloni, C
Bagnato, S
Arighi, A
Arabia, G
Angeloni, R
Keywords: Delphi consensus;Italy;dementia;disease modifying drugs;biological diagnosis;Alzheimer care management
Issue Date: 16-Apr-2025
Publisher: Springer Nature
Citation: Marra, C. et al. (2025) 'Towards a new Value-based scenario for the management of dementia in Italy: a SINdem delphi consensus study', Neurological Sciences, 46 (7), pp. 2913 - 2923. doi: 10.1007/s10072-025-08143-5.
Abstract: This national expert-based Delphi-consensus aims at formulating recommendations on the management of dementia care in Italy. This effort seems important and timely given in light of a new scenario arising from a new biological definition of Alzheimer’s disease (AD) and the availability of disease-modifying treatments (DMTs). Methods: the Steering Committee of the Italian Neurological Society for dementia (SINdem) created appropriate statements. Invited SINdem experts were requested to vote on the statements according to a modified three-round Delphi method. Only those statements reaching Grade A (full agreement ≥ 75%) or B (overall agreement ≥ 80% and full disagreement < 5%) were included in the final document. Round answers’ consistency was graded using the Cohen’s k and within-class correlation coefficient. Results: Forty-six experts voted on 20 statements, which focused on the following aspects: i) organization of care services from early diagnosis to the management of advanced clinical stages; ii) access to biomarkers for a biological diagnosis of AD; iii) requirements necessary for the administration of DMTs; iv) main actors and pathways for the management of patients suffering from cognitive disorders. At the end of the process, 4 statements (20%) received a Grade A consensus, while 16 (80%) reached a Grade B consensus. Although the responses reflect heterogeneity among Italian regions, there was a fair degree of consistency for all statements. Conclusion: The high strength of this expert-based Delphi-consensus may offer guidance for improving the patient’s journey of individuals with cognitive decline from a biological diagnosis to DMTs administration and may possibly offer hints to the Health Systems on dementia.
Description: Code availability: On request to the corresponding Author.
Consortia: On behalf of the SINdem DELPHI Consensus Group: Rossano Angeloni, Gennarina Arabia, Andrea Arighi, Sergio Bagnato, Claudio Babiloni, Roberta Baschi, Giuseppe Bellelli, Valentina Bessi, Edoardo Domenico Giorgio Canu, Sabina Capellari, Moira Ceci, Rosanna Colao, Laura De Togni, Gennaro Della Rocca, Lucia Di Giorgi, Sabrina Esposito, Katia Fabi, Elisabetta Farina, Massimo Filippi, Chiara Fiori, Gianluca Floris, Gianluigi Forloni, Franco Giubilei, Daniela Gragnaniello, Maria Guarino, Alessandro Iavarone, Daniele Imperiale, Valeria Isella, Antonina Luca, Donata Luiselli, Simona Luzzi, Susanna Malagù, Michela Marcon, Alessandro Marti, Alessandro Martorana, Maria Giuseppina Mascia, Patrizia Mecocci, Daniele Mei, Paola Merlo, Fabio Moda, Roberto Monastero, Giuseppe Mura, Anna Maria Musso, Anna Vittoria Marta Orsini, Piero Parchi, Matteo Pardini, Lucilla Parnetti, Andrea Plutino, Gianfranco Puccio, Sabina Roncacci, Mara Rosso, Elisa Rubino, Stefano Sensi, Grazia Sibilia, Marco Spallazzi, Patrizia Sucapane, Pietro Tiraboschi, Gloria Tognoni, Gabriele Tripi, Alessandro Vacca, Marco Vista, Gianluigi Zanusso & Marta Zuffi.
Supplementary Information is available at: https://link.springer.com/article/10.1007/s10072-025-08143-5#Sec7 .
URI: https://bura.brunel.ac.uk/handle/2438/31684
DOI: https://doi.org/10.1007/s10072-025-08143-5
ISSN: 1590-1874
Other Identifiers: ORCiD: Annalena Venneri https://orcid.org/0000-0002-9488-2301
Appears in Collections:Dept of Life Sciences Research Papers

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