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http://bura.brunel.ac.uk/handle/2438/32470| Title: | Network of positive affect and depression in older adults |
| Authors: | Hopkins, EG Leman, PJ Cervin, M Numbers, K Brodaty, H Sachdev, PS Medvedev, ON |
| Keywords: | positive affect;depression;network analysis;older adults;mental health |
| Issue Date: | 24-Oct-2025 |
| Publisher: | Elsevier |
| Citation: | Hopkins, E.G. et al. (2026) 'Network of positive affect and depression in older adults', Journal of Affective Disorders, 394, 120529, pp. 1 - 9. doi: 10.1016/j.jad.2025.120529. |
| Abstract: | Background: Depression in older adults poses significant health challenges, yet the protective role of positive affect remains understudied. This research examined the complex network of positive affect and depression in older adults using advanced network analysis techniques to identify potential targets for intervention. Methods: Bayesian Gaussian Graphical Models and Directed Acyclic Graph modelling were used to analyse associations between ten positive affect variables and depression. Exploratory and confirmatory network analyses ensured stability and node predictability quantified variable influence. Stepwise linear regression confirmed whether specific positive affective variables identified in the networks predicted lower depression scores. Results: Enthusiasm emerged as a key ancestral node with the highest predictability (R2 = 0.65), initiating cascades of positive affect. A primary pathway to depression was identified through feeling active (strength = 1.00, direction = 0.79), with an indirect pathway from feeling enthusiastic via active (strength = 0.98, direction = 0.79) to depression (strength = 1.00, direction = 0.79). Confirmatory longitudinal analysis showed that feeling active and enthusiastic consistently predicted lower depression scores (p < 0.001). The network structure remained stable across analyses. Conclusions: Enthusiasm was identified as a central catalyst in the positive affect network, revealing clear pathways through which positive affect may protect against depression in older adults. Enhancing enthusiastic and active emotional experiences emerged as potential effective, nonpharmacological strategies for preventing and treating depression in older adults. |
| Description: | Data availability:
The data that support the findings of this study are available from the Centre for Healthy Brain Ageing (CHeBA) Research Bank following a standardized request process. Access requests can be directed to CHebaData@unsw.edu.au or to the corresponding author. Data access is restricted due to participant consent terms requiring Older Australian Twins Study (OATS) investigators' review and approval of proposed secondary uses, regardless of data de-identification status.
Analysis code in R is available in the supplemental materials at the end of the manuscript. We report all data exclusions, manipulations, measures, and sample size determinations in the Method section. Supplementary data are available online at: https://www.sciencedirect.com/science/article/pii/S0165032725019718?via%3Dihub#s0080 . |
| URI: | https://bura.brunel.ac.uk/handle/2438/32470 |
| DOI: | https://doi.org/10.1016/j.jad.2025.120529 |
| ISSN: | 0165-0327 |
| Other Identifiers: | ORCiD: Patrick J. Leman https://orcid.org/0000-0003-1708-029X Article number: 120529 |
| Appears in Collections: | Dept of Life Sciences Research Papers |
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| FullText.pdf | Copyright © 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license ( https://creativecommons.org/licenses/by/4.0/ ). | 3.9 MB | Adobe PDF | View/Open |
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