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Title: | Longitudinal evidence of the impact of normal thyroid stimulating hormone variations on cognitive functioning in very old age |
Authors: | Wahlin, A Bunce, D Wahlin, TBR |
Issue Date: | 2008 |
Publisher: | Elsevier |
Citation: | Psychoneuroendocrinology. 30(7): 625-637, Aug 2008 |
Abstract: | The purpose of this study was to examine longitudinal associations among thyroid stimulating hormone (TSH) levels and cognitive performance. Data collected at the first three assessment times, approximately 3 years apart, are reported for the survivors (n=45) from a previously published cross-sectional study. Participants were aged 75–93 years at baseline, and data reported were collected in the Kungsholmen Project, a longitudinal project investigating aging and dementia. Analyses revealed that although declining verbal fluency and visuospatial abilities were accompanied by simultaneously declining TSH levels, the pattern of cross-sectional and longitudinal results are interpreted such that declining TSH levels may have caused episodic memory deficits later on. These results were obtained in the examination of 6-year but not 3-year change, and after removal of the cognitive variation associated with depressive mood symptoms. |
URI: | http://www.elsevier.com/wps/find/journaldescription.cws_home/473/description#description http://bura.brunel.ac.uk/handle/2438/3269 |
ISSN: | 0306-4530 |
Appears in Collections: | Psychology Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
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Longitudinal evidence of the impact of normal thyroid stimulating hormone variations.pdf | 192.79 kB | Adobe PDF | View/Open |
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