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http://bura.brunel.ac.uk/handle/2438/8156
Title: | Path finding methods accounting for stoichiometry in metabolic networks |
Authors: | Pey, J Prada, J Beasley, JE Planes, FJ |
Keywords: | Metabolic networks;Computational biology;Algorithms;Pathways |
Issue Date: | 2011 |
Publisher: | Biomed Central Ltd |
Citation: | Genome Biology, 12, Article R49, 2011 |
Abstract: | Graph-based methods have been widely used for the analysis of biological networks. Their application to metabolic networks has been much discussed, in particular noting that an important weakness in such methods is that reaction stoichiometry is neglected. In this study, we show that reaction stoichiometry can be incorporated into path-finding approaches via mixed-integer linear programming. This major advance at the modeling level results in improved prediction of topological and functional properties in metabolic networks. |
Description: | Copyright © 2011 Pey et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
URI: | http://genomebiology.com/2011/12/5/R49 http://bura.brunel.ac.uk/handle/2438/8156 |
DOI: | http://dx.doi.org/10.1186/gb-2011-12-5-r49 |
ISSN: | 1474-760X |
Appears in Collections: | Publications Dept of Mathematics Research Papers Mathematical Sciences |
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