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Title: | Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes |
Authors: | Simpson, AJ Tufvesson, E Anderson, SD Romer, LM Bjermer, L Kippelen, P |
Keywords: | Exercise-induced bronchoconstriction;Epithelial injury;Inhaled beta(2)-agonist;Clara cell |
Issue Date: | 2013 |
Publisher: | American Physiological Society |
Citation: | Journal of Applied Physiology, 115(10), 1450 - 1456, 2013 |
Abstract: | Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting β2-agonist terbutaline has been shown to reduce dry airflow-induced bronchoconstriction and the associated shedding of airway epithelial cells. Our aim was to test the efficacy of inhaled terbutaline in attenuating hyperpnoea-induced bronchoconstriction and airway epithelial injury in athletes. Twenty-seven athletes with EIB participated in a randomized, double-blind, placebo-controlled, crossover study. Athletes completed an 8-min eucapnic voluntary hyperpnoea (EVH) test with dry air on two separate days 15 min after inhaling 0.5 mg terbutaline or a matching placebo. Forced expiratory volume in 1 s (FEV1) and urinary concentration of the club cell (Clara cell) protein 16 (CC16, a marker of airway epithelial perturbation) were measured before and up to 60 min after EVH. The maximum fall in FEV1 of 17 ± 8% (SD) on placebo was reduced to 8 ± 5% following terbutaline (P < 0.001). Terbutaline gave bronchoprotection (i.e., post-EVH FEV1 fall <10%) to 22 (81%) athletes. EVH caused an increase in urinary excretion of CC16 in both conditions (P < 0.001), and terbutaline significantly reduced this rise (pre- to postchallenge CC16 increase 416 ± 495 pg/μmol creatinine after placebo vs. 315 ± 523 pg/μmol creatinine after terbutaline, P = 0.016). These results suggest that the inhalation of a single therapeutic dose of terbutaline offers significant protection against hyperpnoea-induced bronchoconstriction and attenuates acute airway epithelial perturbation in athletes. |
Description: | This article is made available through the Brunel Open Access Publishing Fund and is distributed by the Creative Commons CC-BY 3.0 license, under which all are free to reuse or distribute the article under the condition that this original publication must be cited. |
URI: | http://jap.physiology.org/content/115/10/1450 http://bura.brunel.ac.uk/handle/2438/8432 |
DOI: | http://dx.doi.org/10.1152/japplphysiol.00716.2013 |
ISSN: | 8750-7587 |
Appears in Collections: | Sport Publications Brunel OA Publishing Fund Dept of Life Sciences Research Papers |
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