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Title: Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema
Authors: Lovering, AT
Romer, LM
Haverkamp, HC
Hokanson, JS
Eldridge, MW
Keywords: Adult;Altitude Sickness;Bronchopulmonary Dysplasia;Exercise;Exercise Test;Exercise Tolerance;Forced Expiratory Flow Rates;Forced Expiratory Volume;Humans;Infant, Newborn;Male;Oxygen Consumption;Pulmonary Edema;Pulmonary Gas Exchange
Issue Date: 2007
Citation: High Altitude Medicine and Biology, 8:1, pp. 62 - 67, 2007
Abstract: A 27-year-old male subject (V(O2 max)), 92% predicted) with a history of bronchopulmonary dysplasia (BPD) and a clinically documented case of high altitude pulmonary edema (HAPE) was examined at rest and during exercise. Pulmonary function testing revealed a normal forced vital capacity (FVC, 98.1% predicted) and diffusion capacity for carbon monoxide (D(L(CO)), 91.2% predicted), but significant airway obstruction at rest [forced expiratory volume in 1 sec (FEV(1)), 66.5% predicted; forced expiratory flow at 50% of vital capacity (FEF(50)), 34.3% predicted; and FEV(1) /FVC 56.5%] that was not reversible with an inhaled bronchodilator. Gas exchange worsened from rest to exercise, with the alveolar to arterial P(O2) difference (AaD(O2)) increasing from 0 at rest to 41 mmHg at maximal normoxic exercise (VO(2) = 41.4 mL/kg/min) and from 11 to 31 mmHg at maximal hypoxic exercise (VO(2) = 21.9 mL/kg/min). Arterial P(O2) decreased to 67.8 and 29.9 mmHg at maximal normoxic and hypoxic exercise, respectively. These data indicate that our subject with a history of BPD is prone to a greater degree of exercise-induced arterial hypoxemia for a given VO(2) and F(I(O2)) than healthy age-matched controls, which may increase the subject's susceptibility to high altitude illness.
ISSN: 1527-0297
Appears in Collections:Sport
Dept of Life Sciences Research Papers

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