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http://bura.brunel.ac.uk/handle/2438/10839
Title: | A potential anti-coagulant role of complement factor H |
Authors: | Ferluga, J Kishore, U Sim, RB |
Keywords: | Anti-phospholipid syndrome;Coagulation;Complement;Factor H |
Issue Date: | 2014 |
Publisher: | Elsevier Ltd |
Citation: | Molecular Immunology, 59(2):188 - 193, (March 2014) |
Abstract: | Anti-phospholipid syndrome (APS) is a complex autoimmune disease, associated with recurrent venous and arterial thrombosis in various tissues. APS is associated with specific antibodies against plasma beta-2 glycoprotein 1 (β2-GP1), and these antibodies react with β2-GP1 bound to negatively charged phospholipids (e.g. cardiolipin) on cell membranes. Some APS patients also have autoantibodies to complement factor H (FH), a homologue of β2-GP1, which also binds to anionic phospholipids. β2-GP1 has earlier been shown to inhibit the intrinsic (contact) activated blood coagulation pathway, promoted by anionic phospholipids. Here we examine whether FH could have similar anti-thrombotic properties. In vitro experiments with surface-bound phospholipids and human plasma, in the presence of FH, confirm this hitherto unreported property of FH. |
URI: | http://www.sciencedirect.com/science/article/pii/S0161589014000406 http://bura.brunel.ac.uk/handle/2438/10839 |
DOI: | http://dx.doi.org/10.1016/j.molimm.2014.02.012 |
ISSN: | 0161-5890 1872-9142 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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