Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/21134
Title: | How HP1 post-translational modifications regulate heterochromatin formation and maintenance |
Authors: | Sales Gil, R Vagnarelli, P |
Keywords: | heterochromatin;HP1;post-translational modifications;centromeres |
Issue Date: | 12-Jun-2020 |
Publisher: | MDPI |
Citation: | Sales-Gil, R. and Vagnarelli, P. (2020) 'How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance', Cells, 9 (6), 1460, pp. 1-13. doi: 10.3390/cells9061460. |
Abstract: | Copyright © 2020 by the authors. Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure. Besides the well-established phosphorylation of histone H3 Ser10 that has been shown to modulate HP1 binding to chromatin, several studies have recently highlighted the importance of HP1 post-translational modifications and additional epigenetic features for the modulation of HP1-chromatin binding ability and heterochromatin formation. In this review, we summarize the recent literature of HP1 post-translational modifications that have contributed to understand how heterochromatin is formed, regulated and maintained. |
URI: | https://bura.brunel.ac.uk/handle/2438/21134 |
DOI: | https://doi.org/10.3390/cells9061460 |
Other Identifiers: | 1460 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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