Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/21742
Title: Targeting Vesicular LGALS3BP by an Antibody-Drug Conjugate as Novel Therapeutic Strategy for Neuroblastoma
Authors: Capone, E
Lamolinara, A
Pastorino, F
Gentile, R
Ponziani, S
Di Vittorio, G
D’Agostino, D
Bibbò, S
Rossi, C
Piccolo, E
Iacobelli, V
Lattanzio, R
Panella, V
Sallese, M
De Laurenzi, V
Giansanti, F
Sala, A
Iezzi, M
Ponzoni, M
Ippoliti, R
Iacobelli, S
Sala, G
Keywords: Antibody-Drug Conjugates (ADC)s;LGALS3BP;neuroblastoma;targeted therapy
Issue Date: Oct-2020
Publisher: MDPI AG
Citation: Cancers, 12 (10), pp. 2989 - 2989
Abstract: Neuroblastoma is the most common extra-cranial solid tumor in infants and children, which accounts for approximately 15% of all cancer-related deaths in the pediatric population. New therapeutic modalities are urgently needed. Antibody-Drug Conjugates (ADC)s-based therapy has been proposed as potential strategy to treat this pediatric malignancy. LGALS3BP is a highly glycosylated protein involved in tumor growth and progression. Studies have shown that LGALS3BP is enriched in extracellular vesicles (EV)s derived by most neuroblastoma cells, where it plays a critical role in preparing a favorable tumor microenvironment (TME) through direct cross talk between cancer and stroma cells. Here, we describe the development of a non-internalizing LGALS3BP ADC, named 1959-sss/DM3, which selectively targets LGALS3BP expressing neuroblastoma. 1959-sss/DM3 mediated potent therapeutic activity in different types of neuroblastoma models. Notably, we found that treatments were well tolerated at efficacious doses that were fully curative. These results offer preclinical proof-of-concept for an ADC targeting exosomal LGALS3BP approach for neuroblastomas.
URI: http://bura.brunel.ac.uk/handle/2438/21742
DOI: http://dx.doi.org/10.3390/cancers12102989
ISSN: http://dx.doi.org/10.3390/cancers12102989
2072-6694
Appears in Collections:Dept of Life Sciences Research Papers

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