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Title: | A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems |
Authors: | Osório, L Silva, E Mackay, R |
Keywords: | organ-on-a-chip;scaffold;tissue engineering;biomaterials;additive manufacturing |
Issue Date: | 6-Aug-2021 |
Publisher: | MDPI |
Citation: | Osório, L. A., Silva, E. and Mackay, R. E. (2021) ‘A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems’, Bioengineering, 8(8), 113, p. 1-.31 doi: 10.3390/bioengineering8080113. |
Abstract: | Copyright: © 2021 by the authors. Drug and chemical development along with safety tests rely on the use of numerous clinical models. This is a lengthy process where animal testing is used as a standard for pre-clinical trials. However, these models often fail to represent human physiopathology. This may lead to poor correlation with results from later human clinical trials. Organ-on-a-Chip (OOAC) systems are engineered microfluidic systems, which recapitulate the physiochemical environment of a specific organ by emulating the perfusion and shear stress cellular tissue undergoes in vivo and could replace current animal models. The success of culturing cells and cell-derived tissues within these systems is dependent on the scaffold chosen; hence, scaffolds are critical for the success of OOACs in research. A literature review was conducted looking at current OOAC systems to assess the advantages and disadvantages of different materials and manufacturing techniques used for scaffold production; and the alternatives that could be tailored from the macro tissue engineering research field. |
URI: | https://bura.brunel.ac.uk/handle/2438/23118 |
DOI: | https://doi.org/10.3390/bioengineering8080113 |
Other Identifiers: | 113 |
Appears in Collections: | Dept of Life Sciences Research Papers Dept of Mechanical and Aerospace Engineering Research Papers |
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