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http://bura.brunel.ac.uk/handle/2438/25406
Title: | Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study |
Authors: | Dake, MD De Marco, M Blackburn, DJ Wilkinson, ID Remes, A Liu, Y Pikkarainen, M Hallikainen, M Soininen, H Venneri, A |
Keywords: | Alzheimer’s disease;body mass index;neuroimaging;overweight |
Issue Date: | 20-Jan-2021 |
Publisher: | IOS Press |
Citation: | Dake, M.D. et al. (2021) 'Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study', Journal of Alzheimer's Disease Reports, 5 (1), pp. 65 - 77. doi: 10.3233/ADR-200267. |
Abstract: | Copyright © 2021– The authors. Background: How the relationship between obesity and MRI-defined neural properties varies across distinct stages of cognitive impairment due to Alzheimer’s disease is unclear. Objective: We used multimodal neuroimaging to clarify this relationship. Methods: Scans were acquired from 47 patients clinically diagnosed with mild Alzheimer’s disease dementia, 68 patients with mild cognitive impairment, and 57 cognitively healthy individuals. Voxel-wise associations were run between maps of gray matter volume, white matter integrity, and cerebral blood flow, and global/visceral obesity. Results: Negative associations were found in cognitively healthy individuals between obesity and white matter integrity and cerebral blood flow of temporo-parietal regions. In mild cognitive impairment, negative associations emerged in frontal, temporal, and brainstem regions. In mild dementia, a positive association was found between obesity and gray matter volume around the right temporoparietal junction. Conclusion: Obesity might contribute toward neural tissue vulnerability in cognitively healthy individuals and mild cognitive impairment, while a healthy weight in mild Alzheimer’s disease dementia could help preserve brain structure in the presence of age and disease-related weight loss. |
URI: | https://bura.brunel.ac.uk/handle/2438/25406 |
DOI: | https://doi.org/10.3233/ADR-200267 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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