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Title: | Functional Brain Connectivity Patterns Associated with Visual Hallucinations in Dementia with Lewy Bodies |
Authors: | Pezzoli, S De Marco, M Zorzi, G Cagnin, A Venneri, A |
Keywords: | dementia with Lewy bodies;functional connectivity;resting-state fMRI;resting-state networks;visual hallucinations |
Issue Date: | 29-Apr-2021 |
Publisher: | IOS Press |
Citation: | Pezzoli, S. et al. (2021) 'Functional Brain Connectivity Patterns Associated with Visual Hallucinations in Dementia with Lewy Bodies', Journal of Alzheimer's Disease Reports, 5 (1), pp. 311 - 320. doi: 10.3233/ADR-200288. |
Abstract: | Copyright © 2021 – The authors. Background: The presence of recurrent, complex visual hallucinations (VH) is among the core clinical features of dementia with Lewy bodies (DLB). It has been proposed that VH arise from a disrupted organization of functional brain networks. However, studies are still limited, especially investigating the resting-state functional brain features underpinning VH in patients with dementia. Objective: The aim of the present pilot study was to investigate whether there were any alterations in functional connectivity associated with VH in DLB. Methods: Seed-based analyses and independent component analysis (ICA) of resting-state fMRI scans were carried out to explore differences in functional connectivity between DLB patients with and without VH. Results: Seed-based analyses reported decreased connectivity of the lateral geniculate nucleus, the superior parietal lobule and the putamen with the medial frontal gyrus in DLB patients with VH. Visual areas showed a pattern of both decreased and increased functional connectivity. ICA revealed between-group differences in the default mode network (DMN). Conclusion: Functional connectivity analyses suggest dysfunctional top-down and bottom-up processes and DMN-related alterations in DLB patients with VH. This impairment might foster the generation of false visual images that are misinterpreted, ultimately resulting in VH. |
Description: | The supplementary material is available in the electronic version of this article: https://doi.org/ 10.3233/ADR-200288. |
URI: | https://bura.brunel.ac.uk/handle/2438/25407 |
DOI: | https://doi.org/10.3233/ADR-200288 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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