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Title: | Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories |
Authors: | Cresto, N Forner-Piquer, I Baig, A Chatterjee, M Perroy, J Goracci, J Marchi, N |
Keywords: | pesticides;neuro-glio-vascular unit;neuroinflammation;neurological disorders;astrocytes;microglia;zebrafish;rodent models;humans |
Issue Date: | 4-Mar-2023 |
Publisher: | Elsevier |
Citation: | Cresto, N. et al. (2023) 'Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories', Chemosphere, 324, 138251, pp. 1 - 17. doi: 10.1016/j.chemosphere.2023.138251. |
Abstract: | Pesticides are omnipresent, and they pose significant environmental and health risks. Translational studies indicate that acute exposure to high pesticide levels is detrimental, and prolonged contact with low concentrations of pesticides, as single and cocktail, could represent a risk factor for multi-organ pathophysiology, including the brain. Within this research template, we focus on pesticides' impact on the blood-brain barrier (BBB) and neuroinflammation, physical and immunological borders for the homeostatic control of the central nervous system (CNS) neuronal networks. We examine the evidence supporting a link between pre- and postnatal pesticide exposure, neuroinflammatory responses, and time-depend vulnerability footprints in the brain. Because of the pathological influence of BBB damage and inflammation on neuronal transmission from early development, varying exposures to pesticides could represent a danger, perhaps accelerating adverse neurological trajectories during aging. Refining our understanding of how pesticides influence brain barriers and borders could enable the implementation of pesticide-specific regulatory measures directly relevant to environmental neuroethics, the exposome, and one-health frameworks. |
Description: | Data availability: No data was used for the research described in the article. |
URI: | https://bura.brunel.ac.uk/handle/2438/28330 |
DOI: | https://doi.org/10.1016/j.chemosphere.2023.138251 |
ISSN: | 0045-6535 |
Other Identifiers: | ORCiD: Isabel Forner-Piquer https://orcid.org/0000-0002-5315-3858 ORCiD: Asma Baig https://orcid.org/0000-0002-3764-1456 ORCiD: Mousumi Chatterjee https://orcid.org/0000-0002-6561-3006 138251 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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