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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/30367
Title: Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction
Authors: Wood, GK
Sargent, BF
Ahmad, Z-U-A
Tharmaratnam, K
Dunai, C
Egbe, FN
Martin, NH
Facer, B
Pendered, SL
Rogers, HC
Hübel, C
van Wamelen, DJ
Bethlehem, RAI
Giunchiglia, V
Hellyer, PJ
Trender, W
Kalsi, G
Needham, E
Easton, A
Jackson, TA
Cunningham, C
Upthegrove, R
Pollak, TA
Hotopf, M
Solomon, T
Pett, SL
Shaw, PJ
Wood, N
Harrison, NA
Miller, KL
Jezzard, P
Williams, G
Duff, EP
Williams, S
Zelaya, F
Smith, SM
Keller, S
Broome, M
Kingston, N
Husain, M
Vincent, A
Bradley, J
Chinnery, P
Menon, DK
Aggleton, JP
Nicholson, TR
Taylor, JP
David, AS
Carson, A
Bullmore, E
Breen, G
Hampshire, A
Zandi, MS
Wong, SH
Venneri, A
Veenith, T
Underwood, J
Thomson, E
Thomas, RH
Tamborska, A
Taams, L
Smith, J
Smith, CJ
Singh, B
Sieradzki, A
Shil, RSK
Semple, S
Seed, AW
Sawcer, SJ
Samuel, M
Salman, RAS
Rota, S
Roberts, A
Peacock, S
Patel, A
Palmos, A
Ostermann, M
Orazulume, O
O’Malley, R
Nicholas, N
Newcombe, V
Nair, A
Mulholland, C
Morris, CM
Monssen, D
McIntosh, AM
McIlwaine, R
McKeever, S
McGlinchey, E
McDonnell, G
Mansoori, P
Madarshahian, D
Keywords: chronic inflammation;encephalopathy;outcomes research;predictive markers;viral infection
Issue Date: 23-Sep-2024
Publisher: Springer Nature
Citation: Wood, K. et al. on behalf of the COVID-CNS Consortium (2024) 'Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction', Nature Medicine, 0 (ahead of print), pp. 1 - 25. doi: 10.1038/s41591-024-03309-8.
Abstract: The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19. Severity of the initial infective insult, postacute psychiatric symptoms and a history of encephalopathy were associated with the greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies.
Description: Data availability: Individual-level data and samples from the COVID-Clinical Neuroscience Study are available for collaborative research by application through the NIHR BioResource Data Access Committee https://bioresource.nihr.ac.uk/using-our-bioresource/apply-for-bioresource-data-access/. The Committee decide on academic applications, with escalation to the NIHR BioResource Steering Committee for contentious applications, and/or applications from industry. Participants in the NIHR BioResource have all consented to the sharing of de-identified data with bona fide researchers worldwide, for research in the public interest. There are limits to these consents both by expectation and legal—some datasets may not be shared beyond a safe setting in the UK. The Data Access Committee aim to process data-only requests as quickly as possible and meet fortnightly to consider applications. Once approved, timeframes for data availability vary from 2 weeks to 6 months depending on the nature of the data requested.
Code availability: Code is publicly available via https://github.com/tnggroup/covidcns.
Extended data are available online at: https://www.nature.com/articles/s41591-024-03309-8#Sec24 .
Supplementary information is available online at: https://www.nature.com/articles/s41591-024-03309-8#Sec25 .
URI: https://bura.brunel.ac.uk/handle/2438/30367
DOI: https://doi.org/10.1038/s41591-024-03309-8
ISSN: 1078-8956
Other Identifiers: ORCiD: Greta K. Wood https://orcid.org/0000-0001-6098-2331
ORCiD: Brendan F. Sargent https://orcid.org/0000-0003-2262-7755
ORCiD: Zain-Ul-Abideen Ahmad https://orcid.org/0000-0002-6940-8851
ORCiD: Kukatharmini Tharmaratnam https://orcid.org/0000-0002-8255-9822
ORCiD: Benedict D. Michael https://orcid.org/0000-0002-8693-8926
ORCiD: Annalena Venneri https://orcid.org/0000-0002-9488-2301
Appears in Collections:Dept of Life Sciences Research Papers

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