Brunel University Research Archive(BURA) preserves and enables easy and open access to all
types of digital content. It showcases Brunel's research outputs.
Research contained within BURA is open access, although some publications may be subject
to publisher imposed embargoes. All awarded PhD theses are also archived on BURA.
Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/31538| Title: | Targeting Peptidyl Arginine Deiminase 4 and NADPH Oxidase Pathways Regulates Neutrophil Dependent Thrombo-inflammation |
| Authors: | Ansari, J Vital, S Esen, E Gavins, F |
| Issue Date: | 13-Dec-2020 |
| Publisher: | Wiley on behalf of The British Pharmacological Society |
| Citation: | Ansari, J. et al. (2020) 'Targeting Peptidyl Arginine Deiminase 4 and NADPH Oxidase Pathways Regulates Neutrophil Dependent Thrombo-inflammation', British Journal of Pharmacology, 178 (2), Abstract number OC004, pp. 409 - 410 (2), pp. 409 - 410. doi: 10.1111/bph.15316. |
| Abstract: | Introduction/Background & aims: Excessive neutrophil extracellular trap (NET) production is associated with the pathogenesis of thrombo-inflammatory diseases e.g. sickle cell disease (SCD), and is catalyzed by the enzyme Peptidyl Arginine Deiminase-4 (PAD4). Neutrophil reactive oxygen species (ROS), especially NADPH-oxidase (NOX) interacts with PAD4 and is critical for its function. Here, we studied the critical role of neutrophilic NOX in NET formation associated with thrombo-inflammation. ... |
| Description: | Meeting abstract presented at Pharmacology 2020, Online, 14-18 December, 2020: Session: Oral Communications - Cardiovascular & Respiratory Pharmacology 1. |
| URI: | https://bura.brunel.ac.uk/handle/2438/31538 |
| DOI: | https://doi.org/10.1111/bph.15316 |
| ISSN: | 0007-1188 |
| Other Identifiers: | ORCiD: Felicity N. E. Gavins https://orcid.org/0000-0001-7008-5423 Abstract number: OC004 |
| Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | Copyright © 2020 The British Pharmacological Society. This is the peer reviewed version of the following article: 'Targeting Peptidyl Arginine Deiminase 4 and NADPH Oxidase Pathways Regulates Neutrophil Dependent Thrombo-inflammation', Selected Abstracts From Pharmacology 2020. Br J Pharmacol, 178: Abstract number OC004, pp. 409-410., which has been published in final form at https://doi.org/10.1111/bph.15316. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions (see: https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html). | 171.21 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.