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http://bura.brunel.ac.uk/handle/2438/32757| Title: | Quality of life and multiple long-term conditions in Southeast Asia: a systematic review and meta-analysis |
| Authors: | Ikhile, D Highton, P Gillies, C Abdala, R Ardavani, A Arora, M Banstola, A Brahmbhatt, A Cassambai, S Funnell, MP Goenka, S Jeffers, S Kondal, D Mohan, S Mulakalapalli, P Oli, N Peace, A Singh, K Vaidya, A Venkateshmurthy, NS Prabhakaran, D Khunti, K |
| Keywords: | outcomes research;quality of life |
| Issue Date: | 26-Jan-2026 |
| Publisher: | Springer Nature |
| Citation: | Ikhile D. et al. (2026) 'Quality of life and multiple long-term conditions in Southeast Asia: a systematic review and meta-analysis', Nature Communications, 0 (ahead of print), pp. 1 - x. doi: 10.1038/s41467-025-68197-z. |
| Abstract: | This review systematically synthesised the evidence on quality of life measures and outcomes for people living with multiple long-term conditions in the Southeast Asia region. Results were analysed using a combination of methods, meta-analysis for studies where the same quality of life score was reported across three or more cohorts, and descriptive narrative synthesis. In total, 34 studies comprising 11,876 participants were included in the narrative synthesis and 14 of these were included in meta-analysis. The most common quality of life tools used included WHOQOL-BREF ( <i>n</i> = 8) and EQ-5D-5L ( <i>n</i> = 3) with pooled mean values of 70.47 (95% CI: 62.71 to 78.24) and 0.76 (95% CI: 0.67 to 0.84) respectively, indicating reduced but good quality of life. As healthcare systems adapt to the evolving challenges associated with multiple long-term conditions, understanding the tools and measures used to assess quality of life in different contexts becomes imperative to account for disease combinations and cultural nuances. |
| Description: | Data availability:
The data informing from this review are extracted from previously published studies in the public domain. The dataset generated and analysed during the review is available on Figshare repository (https://doi.org/10.25392/leicester.data.30156316.v1). "We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply." Supplementary information is available online at: https://www.nature.com/articles/s41467-025-68197-z#Sec16 . |
| URI: | https://bura.brunel.ac.uk/handle/2438/32757 |
| DOI: | https://doi.org/10.1038/s41467-025-68197-z |
| Other Identifiers: | ORCiD: Deborah Ikhile https://orcid.org/0000-0002-4343-1674 ORCiD: Patrick Highton https://orcid.org/0000-0002-0410-5788 ORCiD: Ashkon Ardavani https://orcid.org/0000-0002-9442-3295 ORCiD: Monika Arora https://orcid.org/0000-0001-9987-3933 ORCiD: Amrit Banstola https://orcid.org/0000-0003-3185-9638 ORCiD: Shabana Cassambai https://orcid.org/0000-0001-6201-9063 ORCiD: Mark P. Funnell https://orcid.org/0000-0001-7473-5999 ORCiD: Shifalika Goenka https://orcid.org/0000-0001-6993-2883 ORCiD: Shavez Jeffers https://orcid.org/0000-0001-7542-1772 ORCiD: Prakash Mulakalapalli https://orcid.org/0009-0000-9303-4741 ORCiD: Arron Peace https://orcid.org/0009-0005-3859-2907 ORCiD: Kuldeep Singh https://orcid.org/0000-0002-9375-3233 ORCiD: Nikhil Srinivasapura Venkateshmurthy https://orcid.org/0000-0003-4037-6371 ORCiD: Dorairaj Prabhakaran https://orcid.org/0000-0002-3172-834X |
| Appears in Collections: | Dept of Health Sciences Research Papers |
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