Recurrent mechanisms of biallelic epigenetic inactivation reveal new putative tumour suppressor genes in prostate cancer See

The inactivation of tumour suppressor genes is a key step in cancer development, and is usually achieved by homozygous loss. In prostate cancer, however, large genomic regions are often hemizygously lost, which complicates the identification of putative tumour suppressors in these regions.&#...

Integrated signatures define mutational processes in prostate cancer See

Prostate cancer follows a long and heterogeneous disease course with incompletely understood aetiology¹. Here we dissect the mutational processes shaping the genomes of 959 donors from the Pan Prostate Cancer Group and assess their clinical relevance. By integrating de novo extracted single-...

ERM Culture Alignment to Enhance Competitive Advantage See

The paper discusses the arguments supporting the need for risk culture to transition into ERM culture to be embedded across financial organizations. Creating and maintaining strong ERM culture is paramount to a lasting and meaningful ERM program. It is essential for organizations to...

Resiliency under Strategic Foresight: The effects of Cybersecurity Management and Enterprise Risk Management Alignment See

Rethinking organisations' risk resiliency against cyber risks has been found both successful and lacking because it is more challenging when organisations mirror past siloed approaches. In pursuit of effectiveness and resiliency, this paper examines the antecedents of Cybersecurity Management (CsM...

LLM-enhanced-EA-driven automated optimization framework for joint indoor deployment of multiple BSs and RISs See

The joint deployment of base stations (BSs) and reconfigurable intelligent surfaces (RISs) is considered a promising but underexplored solution to simultaneously improve indoor coverage performance and reduce network costs. Classical evolutionary algorithms (EAs) can solve this bi-objective non-convex mixe...

Communication-Aware Distributed Control for Cooperative Ramp Merging in Vehicular Networks See

Cooperative ramp merging requires reliable coordination among connected vehicles, but practical NR V2X Mode 2 communications may suffer from delay, packet loss, and resource collision due to distributed sidelink resource selection. Existing distributed control methods often assume ideal communication ...

Breastfeeding duration and residential setting in relation to childhood exposure to organochlorine pesticides and PCBs: a longitudinal study of the Rhea cohort in Crete See

Despite decades-old bans, persistent organic pollutants (POPs), including organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), remain a public health concern owing to persistence and bioaccumulation. Previous Rhea mother–child cohort analyses (Crete, Greece) reported notably high DDE (DDT’s ma...

Phytomining potential of naturally colonising vegetation on coal colliery spoil heaps in South Yorkshire, United Kingdom and Upper Silesia, Poland See

The environmental legacy of coal mining is characterised by the widespread accumulation of spoil heaps enriched with elements, representing both a persistent ecological liability and an underutilised secondary resource. Phytomining has emerged as a promising sustainable strategy for the recovery ...

Learning About Intimate Partner Psychological Abuse: An Exploratory Survey of Black Women’s Recollections See

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